Jeux à deux joueurs ou plus
Voici une liste des jeux MSX jouables à plusieurs en coopératif ou en compétitif (VS).
| Titre | Nombre | Mode |
| A1 Spirit | ||
| Breaker (Radarsoft) | ||
| Bubble Bobble | 2 | Coop |
| Butaporc (T&E Soft) | ||
| Columns | ||
| Don't Cock It Up (Matra) | ||
| Dunkshot | ||
| F1 Spirit (Konami) | ||
| F1-Spirit 3D Special | ||
| Family Boxing (Sony) | ||
| Field Master | ||
| Fighters Ragnarok (DeltaZ) | ||
| Gambare Goemon | 2 | Coop |
| Gauntlet | ||
| Girly Block | ||
| Go Board (Konami GAME COLLECTION SPECIAL) | ||
| Greatest Driver (T&E Soft) | ||
| Heroes Arena (Imanok/msxdev) | ||
| Hyper Olympic | ||
| Hyper Sport | ||
| Ikari Warriors | ||
| Konami's Baseball | ||
| Konami's Boxing | ||
| Konami's Foot | ||
| Konami's Ping Pong | ||
| Konami's Tennis | ||
| Kralizec's Tetris | ||
| Lick et Mick | ||
| Niko2 (Wolfteam) | ||
| Othello | VS | |
| Pennant Race | ||
| Pennant Race 2 | ||
| Puyo Puyo | VS | |
| QBIQS (Z80ST/msxdev) | ||
| Quarth | ||
| Quimpl | 2 | Coop |
| Rune Master 1 | VS | |
| Rune Master 2 | VS | |
| Rune Master 3 | VS | |
| Salamander | 2 | Coop |
| Spy Vs Spy 2 | ||
| Super Laydock | ||
| Super Runner | VS | |
| Title Awase (Konami GAME COLLECTION SPECIAL) | ||
| Twin Bee | ||
| Warroid | ||
| Yie ar kung fu 2 | 2 | VS |